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COMMUNICATIONS
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2293-2296
Structure-Based Design and Synthesis of a Potent Matrix Metalloproteinase-13 Inhibitor Based on a Pyrrolidinone Scaffold
Ralph P. Robinson,
Ellen R. Laird,
James F. Blake,
Jon Bordner,
Kathleen M. Donahue,
Lori L. Lopresti-Morrow,
Peter G. Mitchell,
Matthew R. Reese,
Lisa M. Reeves,
Ethan J. Stam, and
Sue A. Yocum
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2297-2299
Fenchylamine Sulfonamide Inhibitors of Amyloid  Peptide Production by the  -Secretase Proteolytic Pathway: Potential Small-Molecule Therapeutic Agents for the Treatment of Alzheimer's Disease
Gilbert M. Rishton,
Daniel M. Retz,
Paul A. Tempest,
James Novotny,
Steve Kahn,
James J. S. Treanor,
Jack D. Lile, and
Martin Citron
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ARTICLES
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2300-2309
A 3D-QSAR Study on the Structural Requirements for Binding to CB1 and CB2 Cannabinoid Receptors
Maria Fichera,
Gabriele Cruciani,
Alfredo Bianchi, and
Giuseppe Musumarra
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2310-2323
New Anilinophthalazines as Potent and Orally Well Absorbed Inhibitors of the VEGF Receptor Tyrosine Kinases Useful as Antagonists of Tumor-Driven Angiogenesis
Guido Bold,
Karl-Heinz Altmann,
Jörg Frei,
Marc Lang,
Paul W. Manley,
Peter Traxler,
Bernhard Wietfeld,
Josef Brüggen,
Elisabeth Buchdunger,
Robert Cozens,
Stefano Ferrari,
Pascal Furet,
Francesco Hofmann,
Georg Martiny-Baron,
Jürgen Mestan,
Johannes Rösel,
Matthew Sills,
David Stover,
Figan Acemoglu,
Eugen Boss,
René Emmenegger,
Laurent Lässer,
Elvira Masso,
Rosemarie Roth,
Christian Schlachter,
Werner Vetterli,
Dominique Wyss, and
Jeanette M. Wood
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2324-2331
Hydroxamic Acid Derivatives as Potent Peptide Deformylase Inhibitors and Antibacterial Agents
Christian Apfel,
David W. Banner,
Daniel Bur,
Michel Dietz,
Takahiro Hirata,
Christian Hubschwerlen,
Hans Locher,
Malcolm G. P. Page,
Wolfgang Pirson,
Gérard Rossé, and
Jean-Luc Specklin
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2332-2349
17-O-Aminoalkyloximes of 5-Androstane-3,14-diol with Digitalis-like Activity: Synthesis, Cardiotonic Activity, Structure-Activity Relationships, and Molecular Modeling of the Na+,K+-ATPase Receptor
Alberto Cerri,
Nicoletta Almirante,
Paolo Barassi,
Alessandra Benicchio,
Giorgio Fedrizzi,
Patrizia Ferrari,
Rosella Micheletti,
Luisa Quadri,
Enzio Ragg,
Roberto Rossi,
Marco Santagostino,
Antonio Schiavone,
Fulvio Serra,
Maria Pia Zappavigna, and
Piero Melloni
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2350-2355
CCK Peptides with Combined Features of Hexa- and Tetrapeptide CCK-A Agonists
M. Edward Pierson,
Jeanne M. Comstock,
Roy D. Simmons,
Ronald Julien,
Frederick Kaiser, and
James D. Rosamond
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2356-2361
Synthesis and Biological Evaluation of Bombesin Constrained Analogues
Michèle Cristau,
Chantal Devin,
Catherine Oiry,
Olivier Chaloin,
Muriel Amblard,
Nicole Bernad,
Annie Heitz,
Jean-Alain Fehrentz, and
Jean Martinez
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2362-2370
Design, Synthesis, and Structure-Activity Relationships of Novel Non-Imidazole Histamine H3 Receptor Antagonists
Ian D. Linney,
Ildiko M. Buck,
Elaine A. Harper,
S. Barret Kalindjian,
Michael J. Pether,
Nigel P. Shankley,
Gillian F. Watt, and
Paul T. Wright
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2371-2381
Indeno[1,2-b]pyrazin-2,3-diones: A New Class of Antagonists at the Glycine Site of the NMDA Receptor with Potent in Vivo Activity
Patrick Jimonet,
Yves Ribeill,
Georg Andrees Bohme,
Alain Boireau,
Michel Chevé,
Dominique Damour,
Adam Doble,
Arielle Genevois-Borella,
Frédéric Herman,
Assunta Imperato,
Sylvain Le Guern,
Franco Manfré,
Jeremy Pratt,
John C. R. Randle,
Jean-Marie Stutzmann, and
Serge Mignani
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2382-2386
Synthesis and Biological Evaluation of Bradykinin B1/B2 and Selective B1 Receptor Antagonists
Muriel Amblard,
Philippe Bedos,
Christophe Olivier,
Isabelle Daffix,
Jean-Michel Luccarini,
Pierre Dodey,
Didier Pruneau,
Jean-Luc Paquet, and
Jean Martinez
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2387-2394
A Rational Approach to the Design and Synthesis of a New Bradykinin B1 Receptor Antagonist
Philippe Bedos,
Muriel Amblard,
Gilles Subra,
Pierre Dodey,
Jean-Michel Luccarini,
Jean-Luc Paquet,
Didier Pruneau,
André Aumelas, and
Jean Martinez
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2395-2402
Synthesis and Cytotoxic and Antitumor Activity of Benzo[b]pyrano[3,2-h]acridin-7-one Analogues of Acronycine
Nadine Costes,
Hervé Le Deit,
Sylvie Michel,
François Tillequin,
Michel Koch,
Bruno Pfeiffer,
Pierre Renard,
Stéphane Léonce,
Nicolas Guilbaud,
Laurence Kraus-Berthier,
Alain Pierré, and
Ghanem Atassi
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2403-2410
Water-Soluble, Core-Modified Porphyrins as Novel, Longer-Wavelength-Absorbing Sensitizers for Photodynamic Therapy
Corey E. Stilts,
Marina I. Nelen,
David G. Hilmey,
Sherry R. Davies,
Sandra O. Gollnick,
Allan R. Oseroff,
Scott L. Gibson,
Russell Hilf, and
Michael R. Detty
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2411-2418
X-ray Structure of Cytotoxic trans-[PtCl2(dimethylamine)(isopropylamine)]: Interstrand Cross-Link Efficiency, DNA Sequence Specificity, and Inhibition of the B-Z Transition
José M. Pérez,
Eva I. Montero,
Ana M. González,
Xavier Solans,
Mercé Font-Bardia,
Miguel A. Fuertes,
Carlos Alonso, and
Carmen Navarro-Ranninger
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2419-2429
Synthesis of B-Ring Homologated Estradiol Analogues that Modulate Tubulin Polymerization and Microtubule Stability
Zhiqiang Wang,
Donglai Yang,
Arasambattu K. Mohanakrishnan,
Phillip E. Fanwick,
Priya Nampoothiri,
Ernest Hamel, and
Mark Cushman
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2430-2437
Design, Synthesis, and Biological Evaluation of Tricyclic Nucleosides (Dimensional Probes) as Analogues of Certain Antiviral Polyhalogenated Benzimidazole Ribonucleosides
Zhijian Zhu,
Blaise Lippa,
John C. Drach, and
Leroy B. Townsend
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2438-2448
Deoxy Sugar Analogues of Triciribine: Correlation of Antiviral and Antiproliferative Activity with Intracellular Phosphorylation
Anthony R. Porcari,
Roger G. Ptak,
Katherine Z. Borysko,
Julie M. Breitenbach,
Sauro Vittori,
Linda L. Wotring,
John C. Drach, and
Leroy B. Townsend
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2449-2456
Synthesis and Antiviral Evaluation of Trisubstituted Indole N-Nucleosides as Analogues of 2,5,6-Trichloro-1-(-D-ribofuranosyl)benzimidazole (TCRB)
Jiong J. Chen,
Yuan Wei,
John C. Drach, and
Leroy B. Townsend
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2457-2463
6-N-Acyltriciribine Analogues: Structure-Activity Relationship between Acyl Carbon Chain Length and Activity against HIV-1
Anthony R. Porcari,
Roger G. Ptak,
Katherine Z. Borysko,
Julie M. Breitenbach,
John C. Drach, and
Leroy B. Townsend
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2464-2472
Synthesis and Antiviral Evaluation of Halogenated -D- and -L-Erythrofuranosylbenzimidazoles
Kristjan S. Gudmundsson,
Jeffrey Tidwell,
Nicole Lippa,
George W. Koszalka,
Nanine van Draanen,
Roger G. Ptak,
John C. Drach, and
Leroy B. Townsend
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BRIEF ARTICLES
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2473-2478
Synthesis of Fluorosugar Analogues of 2,5,6-Trichloro-1-(-D-ribofuranosyl)benzimidazole as Antivirals with Potentially Increased Glycosidic Bond Stability
Kristjan S. Gudmundsson,
George A. Freeman,
John C. Drach, and
Leroy B. Townsend
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2479-2483
A Potent Aldose Reductase Inhibitor, (2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): Its Absolute Configuration and Interactions with the Aldose Reductase by X-ray Crystallography
Mitsuru Oka,
Yukiharu Matsumoto,
Shigeru Sugiyama,
Nobuaki Tsuruta, and
Masaaki Matsushima
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2484-2487
Polyether Mimics of Naturally Occurring Cytotoxic Annonaceous Acetogenins
Zhu-Jun Yao,
Hai-Ping Wu, and
Yu-Lin Wu
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BOOK REVIEWS
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2488-2488
| Comprehensive Organic Transformations. A Guide to Functional Group Preparations By Richard A. Larock. Wiley-VCH Publishers, New York. 1999. xliii + 2583 pp. 18.5 × 26 cm. ISBN 0-471-19031-4. $150.00.
Jan W. F. Wasley
[Full Article - PDF] | |